{"id":5074,"date":"2026-06-09T14:37:55","date_gmt":"2026-06-09T14:37:55","guid":{"rendered":"https:\/\/erasmusoic.nl\/?page_id=5074"},"modified":"2026-06-09T14:37:55","modified_gmt":"2026-06-09T14:37:55","slug":"publications-2025","status":"publish","type":"page","link":"https:\/\/erasmusoic.nl\/2020\/publications-and-theses\/publications-2025\/","title":{"rendered":"Publications 2025"},"content":{"rendered":"\n

Publications in which OIC equipment was used<\/h2>\n\n\n\n
    \n
  1. L. Arkush et al., Biallelic MED29 variants cause pontocerebellar hypoplasia with cataracts. European Journal of Human Genetics 33, 1271-1280 (2025).<\/li>\n\n\n\n
  2. I. B\u00e4r et al., The severe von Willebrand disease variant p.M771V leads to impaired anterograde trafficking of von Willebrand factor in patient-derived and base-edited endothelial colony-forming cells. Journal of Thrombosis and Haemostasis 23, 466-479 (2025).<\/li>\n\n\n\n
  3. I. B\u00e4r et al., Allele-selective Disruption of Pathogenic VWF Variants in Type 2 Von Willebrand Disease using CRISPR\/Cas9. Blood Advances 10.1182\/bloodadvances.2025018760 (2025).<\/li>\n\n\n\n
  4. D. Barata et al., Simple and high-containment lung-on-chip model for studying respiratory viral infections using human primary lung cells. Materials Today Bio 35 (2025).<\/li>\n\n\n\n
  5. L. W. J. Bosman et al., A Del(5Ncf1-Fkbp6) mouse model of Williams syndrome shows coronary, aortic, and cerebral vascular abnormalities with behavioral deficits. PNAS Nexus 4 (2025).<\/li>\n\n\n\n
  6. M. Bouckaert et al., Generation of two iPSC lines (UGENTi003 and UGENTi004) from patients with intermediate rod-cone dystrophy carrying the c.[-123C>T;701G>A];[806_810del] variants in the RDH12 gene. Stem Cell Research 86 (2025).<\/li>\n\n\n\n
  7. B. L. J. Bouwen et al., Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures. Nature Communications 16 (2025).<\/li>\n\n\n\n
  8. F. Catalano et al., Domain-substituted IGF2 tag modulates targeting of lentiviral gene therapy for Hunter syndrome. EMBO Molecular Medicine 17, 3197-3226 (2025).<\/li>\n\n\n\n
  9. V. Cherdyntseva et al., Nucleoplasmic Lamin A\/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels. Nature Communications 16 (2025).<\/li>\n\n\n\n
  10. H. Crielaard et al., The effect of presence and location of microcalcifications on atherosclerotic plaque rupture. A tissue-engineering approach 171 (2025).<\/li>\n\n\n\n
  11. H. Crielaard et al., Local characterization of collagen architecture and mechanical properties of tissue engineered atherosclerotic plaque cap analogs. Acta Biomaterialia 194, 185-193 (2025).<\/li>\n\n\n\n
  12. V. Dinatale et al., Exploring Si-phthalocyanines with different valency for PSMA-targeted photodynamic therapy. Synthesis and preclinical validation 290 (2025).<\/li>\n\n\n\n
  13. F. D. Duzanic et al., H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability. EMBO Journal 44, 6598-6625 (2025).<\/li>\n\n\n\n
  14. P. A. M. Engbers et al., Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses. EJNMMI Research 15 (2025).<\/li>\n\n\n\n
  15. A. K. Felder et al., Reactivation of developmentally silenced globin genes through forced linear recruitment of remote enhancers. Blood 146, 732-744 (2025).<\/li>\n\n\n\n
  16. S. F. Fobian, M. Amin, A. Sacchetti, A. L. Oei, T. L. M. ten Hagen, Investigating the delivery of PD-L1-targeted immunoliposomes in a dynamic cervical cancer-on-a-chip model. Journal of Controlled Release 379, 236-250 (2025).<\/li>\n\n\n\n
  17. S. A. Ghisai et al., Transcriptomic analysis of EGFR co-expression and activation in glioblastoma reveals associations with its ligands. Neurooncol Adv 7, vdae229 (2025).<\/li>\n\n\n\n
  18. R. Giles et al., Animal-free alternatives for Matrigel in human iPSC-derived blood vessel organoid culture. Scientific Reports 15 (2025).<\/li>\n\n\n\n
  19. C. E. Hansen et al., Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction. Cell Death and Disease 16 (2025).<\/li>\n\n\n\n
  20. T. Heemskerk et al., Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells. Clinical and Translational Radiation Oncology 51 (2025).<\/li>\n\n\n\n
  21. T. Heemskerk et al., A Novel Live-Cell Microscopy Platform for Real-Time Visualization of 53BP1 Foci Dynamics and Accurate Dosimetry in Proton Therapy. Physica Medica 135 (2025).<\/li>\n\n\n\n
  22. T. Heemskerk, G. van de Kamp, M. Rovituso, R. Kanaar, J. Essers, Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency. Clinical and Translational Radiation Oncology 51 (2025).<\/li>\n\n\n\n
  23. I. L. Jansen, D. \u015eahin, F. J. H. Gijsen, E. Farrell, K. van der Heiden, Modelling Atherosclerotic Plaque Cap Mechanics. Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell-Based Model 9 (2025).<\/li>\n\n\n\n
  24. Z. M. Komar et al., Motion based ex vivo (MOTEX) culture of breast tumor slices sustains microenvironment composition. Neoplasia (United States) 68 (2025).<\/li>\n\n\n\n
  25. Z. M. Komar et al., Curcumin Induces Homologous Recombination Deficiency by BRCA2 Degradation in Breast Cancer and Normal Cells. Cancers 17 (2025).<\/li>\n\n\n\n
  26. Z. M. Komar et al., Development and validation of a functional ex vivo paclitaxel and eribulin sensitivity assay for breast cancer, the REMIT assay. npj Breast Cancer 11 (2025).<\/li>\n\n\n\n
  27. K. Kroh et al., A comparative analysis of the dendritic cell response upon exposure to different rabies virus strains. PLoS Neglected Tropical Diseases 19 (2025).<\/li>\n\n\n\n
  28. F. Krstanovi\u0107 et al., Neuron-restricted cytomegalovirus latency in the central nervous system regulated by CD4+ T-cells and IFN-\u03b3. Journal of Neuroinflammation 22 (2025).<\/li>\n\n\n\n
  29. R. Kuthethur et al., FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments. Science 390 (2025).<\/li>\n\n\n\n
  30. B. M. Laksono et al., Elucidating the role of human skeletal muscles in the pathogenesis of enterovirus D68 infection. Life Science Alliance 8 (2025).<\/li>\n\n\n\n
  31. S. Li et al., Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels. Oncogene 44, 805-819 (2025).<\/li>\n\n\n\n
  32. K. Liu et al., Macrophage-augmented organoids recapitulate the complex pathophysiology of viral diseases and enable development of multitarget therapeutics. Nature Biomedical Engineering 9, 1848-1868 (2025).<\/li>\n\n\n\n
  33. M. Maric et al., EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers. Nature Communications 16 (2025).<\/li>\n\n\n\n
  34. S. Oukrich et al., Early fibrin biofilm development in cardiovascular infections. Biofilm 9 (2025).<\/li>\n\n\n\n
  35. D. Poel et al., Elacridar improves sunitinib efficacy in colorectal cancer models. European Journal of Pharmaceutical Sciences 212 (2025).<\/li>\n\n\n\n
  36. C. Posthoorn-Verheul et al., Optimized culturing yields high success rates and preserves molecular heterogeneity, enabling personalized screening for high-grade gliomas. npj Precision Oncology 9 (2025).<\/li>\n\n\n\n
  37. A. Rajicic et al., WDR49-Positive Astrocytes Mark Severity of Neurodegeneration in Frontotemporal Lobar Degeneration\u00a0and Alzheimer’s Disease. GLIA 73, 948-968 (2025).<\/li>\n\n\n\n
  38. Z. Ren, X. Wang, M. Angelov, C. I. De Zeeuw, Z. Gao, Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing. Nature Communications 16, 612 (2025).<\/li>\n\n\n\n
  39. M. Rissmann et al., A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies. PLoS Pathogens 21 (2025).<\/li>\n\n\n\n
  40. I. Salas-Armenteros, M. Klunder, W. Vermeulen, M. Tresini, Crosstalk between chromatin state and ATM signalling in DNA damage-induced transcription stress. EMBO Journal 44, 5564-5594 (2025).<\/li>\n\n\n\n
  41. M. J. Sarink et al., Acanthamoeba castellanii Can Facilitate Plasmid Transfer Between Environmental Pseudomonas spp. Journal of Basic Microbiology 65 (2025).<\/li>\n\n\n\n
  42. M. J. Sarink et al., Acanthamoeba castellanii trophozoites need oxygen for normal functioning and lipids are their preferred substrate, offering new possibilities for treatment. International Journal for Parasitology 55, 35-44 (2025).<\/li>\n\n\n\n
  43. M. P. Scholtes et al., Integrative analysis of patient-derived tumoroids and ex vivo organoid modelling of ARID1A loss in bladder cancer reveals therapeutic molecular targets. Cancer Letters 614, 217506 (2025).<\/li>\n\n\n\n
  44. M. M. Sisakht et al., Cost-reduction strategy to culture patient derived bladder tumor organoids. Scientific Reports 15 (2025).<\/li>\n\n\n\n
  45. D. Sproviero et al., A blood-based DNA damage signature in patients with Parkinson\u2019s disease is associated with disease progression. Nature Aging 5, 1844-1861 (2025).<\/li>\n\n\n\n
  46. R. Stabile et al., The nucleosome remodeling and deacetylase-SWItch\/sucrose non-fermentable antagonism regulates the coordinated activation of epithelial-To-mesenchymal transition and inflammation in oral cancer. Journal of the National Cancer Institute 117, 1438-1455 (2025).<\/li>\n\n\n\n
  47. S. J. M. Stefens et al., Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS-STING Pathway and Reverses Macrophage-Like VSMC Phenotypes in Progeroid DNA-Repair-Deficient Ercc1\u0394\/- Mice. Aging Cell 24 (2025).<\/li>\n\n\n\n
  48. L. Stockmann et al., KIF2A stabilizes intercellular bridge microtubules to maintain mouse embryonic stem cell cytokinesis. The Journal of cell biology 224 (2025).<\/li>\n\n\n\n
  49. J. Van De Grint et al., A Reporter Platform to Study Therapy-Induced Senescence in Live Cancer Cells. Small Methods 9 (2025).<\/li>\n\n\n\n
  50. G. van de Kamp, I. T. da Silva, S. Barnhoorn, R. Kanaar, J. Essers, Contributions of DNA double strand break repair pathways to DNA crosslink repair. DNA Repair 153 (2025).<\/li>\n\n\n\n
  51. G. van de Kamp, T. Heemskerk, M. Rovituso, R. Kanaar, J. Essers, Differential roles of DNA double strand break repair pathways in response to X-ray, proton, and alpha-particle irradiation. International Journal of Radiation Biology 102, 105-115 (2025).<\/li>\n\n\n\n
  52. E. D. van Deel et al., Induction of cardiac fibulin-4 protects against pressure overload-induced cardiac hypertrophy and heart failure. Communications Biology 8 (2025).<\/li>\n\n\n\n
  53. J. W. van der Meer et al., Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1. Genes and Development 39, 401-422 (2025).<\/li>\n\n\n\n
  54. C. van Horik et al., The impact of hyperoxia and antibiotics on lung mesenchymal cells in experimental bronchopulmonary dysplasia. American journal of physiology Lung cellular and molecular physiology 329, L440-L454 (2025).<\/li>\n\n\n\n
  55. J. D. Windster et al., Human enteric glia diversity in health and disease. new avenues for the treatment of Hirschsprung disease 168, 965-979 (2025).<\/li>\n\n\n\n
  56. H. Wu et al., Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes. Disease Models & Mechanisms 18 (2025).<\/li>\n\n\n\n
  57. C. Yang et al., Fingolimod Prevents Neuroinflammation but Has a Limited Effect on the Development of Ataxia in a Mouse Model for SCA1. International Journal of Molecular Sciences 26 (2025).<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Publications in which OIC equipment was used<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":1780,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-5074","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false,"twentytwenty-fullscreen":false},"uagb_author_info":{"display_name":"Martijn de Gruiter","author_link":"https:\/\/erasmusoic.nl\/2020\/author\/martijn-de-gruiter\/"},"uagb_comment_info":0,"uagb_excerpt":"Publications in which OIC equipment was used","_links":{"self":[{"href":"https:\/\/erasmusoic.nl\/2020\/wp-json\/wp\/v2\/pages\/5074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/erasmusoic.nl\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/erasmusoic.nl\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/erasmusoic.nl\/2020\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/erasmusoic.nl\/2020\/wp-json\/wp\/v2\/comments?post=5074"}],"version-history":[{"count":3,"href":"https:\/\/erasmusoic.nl\/2020\/wp-json\/wp\/v2\/pages\/5074\/revisions"}],"predecessor-version":[{"id":5123,"href":"https:\/\/erasmusoic.nl\/2020\/wp-json\/wp\/v2\/pages\/5074\/revisions\/5123"}],"up":[{"embeddable":true,"href":"https:\/\/erasmusoic.nl\/2020\/wp-json\/wp\/v2\/pages\/1780"}],"wp:attachment":[{"href":"https:\/\/erasmusoic.nl\/2020\/wp-json\/wp\/v2\/media?parent=5074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}