Publications 2025

Publications in which OIC equipment was used

  1. L. Arkush et al., Biallelic MED29 variants cause pontocerebellar hypoplasia with cataracts. European Journal of Human Genetics 33, 1271-1280 (2025).
  2. I. Bär et al., The severe von Willebrand disease variant p.M771V leads to impaired anterograde trafficking of von Willebrand factor in patient-derived and base-edited endothelial colony-forming cells. Journal of Thrombosis and Haemostasis 23, 466-479 (2025).
  3. I. Bär et al., Allele-selective Disruption of Pathogenic VWF Variants in Type 2 Von Willebrand Disease using CRISPR/Cas9. Blood Advances 10.1182/bloodadvances.2025018760 (2025).
  4. D. Barata et al., Simple and high-containment lung-on-chip model for studying respiratory viral infections using human primary lung cells. Materials Today Bio 35 (2025).
  5. L. W. J. Bosman et al., A Del(5Ncf1-Fkbp6) mouse model of Williams syndrome shows coronary, aortic, and cerebral vascular abnormalities with behavioral deficits. PNAS Nexus 4 (2025).
  6. M. Bouckaert et al., Generation of two iPSC lines (UGENTi003 and UGENTi004) from patients with intermediate rod-cone dystrophy carrying the c.[-123C>T;701G>A];[806_810del] variants in the RDH12 gene. Stem Cell Research 86 (2025).
  7. B. L. J. Bouwen et al., Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures. Nature Communications 16 (2025).
  8. F. Catalano et al., Domain-substituted IGF2 tag modulates targeting of lentiviral gene therapy for Hunter syndrome. EMBO Molecular Medicine 17, 3197-3226 (2025).
  9. V. Cherdyntseva et al., Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels. Nature Communications 16 (2025).
  10. H. Crielaard et al., The effect of presence and location of microcalcifications on atherosclerotic plaque rupture. A tissue-engineering approach 171 (2025).
  11. H. Crielaard et al., Local characterization of collagen architecture and mechanical properties of tissue engineered atherosclerotic plaque cap analogs. Acta Biomaterialia 194, 185-193 (2025).
  12. V. Dinatale et al., Exploring Si-phthalocyanines with different valency for PSMA-targeted photodynamic therapy. Synthesis and preclinical validation 290 (2025).
  13. F. D. Duzanic et al., H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability. EMBO Journal 44, 6598-6625 (2025).
  14. P. A. M. Engbers et al., Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses. EJNMMI Research 15 (2025).
  15. A. K. Felder et al., Reactivation of developmentally silenced globin genes through forced linear recruitment of remote enhancers. Blood 146, 732-744 (2025).
  16. S. F. Fobian, M. Amin, A. Sacchetti, A. L. Oei, T. L. M. ten Hagen, Investigating the delivery of PD-L1-targeted immunoliposomes in a dynamic cervical cancer-on-a-chip model. Journal of Controlled Release 379, 236-250 (2025).
  17. S. A. Ghisai et al., Transcriptomic analysis of EGFR co-expression and activation in glioblastoma reveals associations with its ligands. Neurooncol Adv 7, vdae229 (2025).
  18. R. Giles et al., Animal-free alternatives for Matrigel in human iPSC-derived blood vessel organoid culture. Scientific Reports 15 (2025).
  19. C. E. Hansen et al., Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction. Cell Death and Disease 16 (2025).
  20. T. Heemskerk et al., Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells. Clinical and Translational Radiation Oncology 51 (2025).
  21. T. Heemskerk et al., A Novel Live-Cell Microscopy Platform for Real-Time Visualization of 53BP1 Foci Dynamics and Accurate Dosimetry in Proton Therapy. Physica Medica 135 (2025).
  22. T. Heemskerk, G. van de Kamp, M. Rovituso, R. Kanaar, J. Essers, Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency. Clinical and Translational Radiation Oncology 51 (2025).
  23. I. L. Jansen, D. Şahin, F. J. H. Gijsen, E. Farrell, K. van der Heiden, Modelling Atherosclerotic Plaque Cap Mechanics. Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell-Based Model 9 (2025).
  24. Z. M. Komar et al., Motion based ex vivo (MOTEX) culture of breast tumor slices sustains microenvironment composition. Neoplasia (United States) 68 (2025).
  25. Z. M. Komar et al., Curcumin Induces Homologous Recombination Deficiency by BRCA2 Degradation in Breast Cancer and Normal Cells. Cancers 17 (2025).
  26. Z. M. Komar et al., Development and validation of a functional ex vivo paclitaxel and eribulin sensitivity assay for breast cancer, the REMIT assay. npj Breast Cancer 11 (2025).
  27. K. Kroh et al., A comparative analysis of the dendritic cell response upon exposure to different rabies virus strains. PLoS Neglected Tropical Diseases 19 (2025).
  28. F. Krstanović et al., Neuron-restricted cytomegalovirus latency in the central nervous system regulated by CD4+ T-cells and IFN-γ. Journal of Neuroinflammation 22 (2025).
  29. R. Kuthethur et al., FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments. Science 390 (2025).
  30. B. M. Laksono et al., Elucidating the role of human skeletal muscles in the pathogenesis of enterovirus D68 infection. Life Science Alliance 8 (2025).
  31. S. Li et al., Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels. Oncogene 44, 805-819 (2025).
  32. K. Liu et al., Macrophage-augmented organoids recapitulate the complex pathophysiology of viral diseases and enable development of multitarget therapeutics. Nature Biomedical Engineering 9, 1848-1868 (2025).
  33. M. Maric et al., EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers. Nature Communications 16 (2025).
  34. S. Oukrich et al., Early fibrin biofilm development in cardiovascular infections. Biofilm 9 (2025).
  35. D. Poel et al., Elacridar improves sunitinib efficacy in colorectal cancer models. European Journal of Pharmaceutical Sciences 212 (2025).
  36. C. Posthoorn-Verheul et al., Optimized culturing yields high success rates and preserves molecular heterogeneity, enabling personalized screening for high-grade gliomas. npj Precision Oncology 9 (2025).
  37. A. Rajicic et al., WDR49-Positive Astrocytes Mark Severity of Neurodegeneration in Frontotemporal Lobar Degeneration and Alzheimer’s Disease. GLIA 73, 948-968 (2025).
  38. Z. Ren, X. Wang, M. Angelov, C. I. De Zeeuw, Z. Gao, Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing. Nature Communications 16, 612 (2025).
  39. M. Rissmann et al., A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies. PLoS Pathogens 21 (2025).
  40. I. Salas-Armenteros, M. Klunder, W. Vermeulen, M. Tresini, Crosstalk between chromatin state and ATM signalling in DNA damage-induced transcription stress. EMBO Journal 44, 5564-5594 (2025).
  41. M. J. Sarink et al., Acanthamoeba castellanii Can Facilitate Plasmid Transfer Between Environmental Pseudomonas spp. Journal of Basic Microbiology 65 (2025).
  42. M. J. Sarink et al., Acanthamoeba castellanii trophozoites need oxygen for normal functioning and lipids are their preferred substrate, offering new possibilities for treatment. International Journal for Parasitology 55, 35-44 (2025).
  43. M. P. Scholtes et al., Integrative analysis of patient-derived tumoroids and ex vivo organoid modelling of ARID1A loss in bladder cancer reveals therapeutic molecular targets. Cancer Letters 614, 217506 (2025).
  44. M. M. Sisakht et al., Cost-reduction strategy to culture patient derived bladder tumor organoids. Scientific Reports 15 (2025).
  45. D. Sproviero et al., A blood-based DNA damage signature in patients with Parkinson’s disease is associated with disease progression. Nature Aging 5, 1844-1861 (2025).
  46. R. Stabile et al., The nucleosome remodeling and deacetylase-SWItch/sucrose non-fermentable antagonism regulates the coordinated activation of epithelial-To-mesenchymal transition and inflammation in oral cancer. Journal of the National Cancer Institute 117, 1438-1455 (2025).
  47. S. J. M. Stefens et al., Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS-STING Pathway and Reverses Macrophage-Like VSMC Phenotypes in Progeroid DNA-Repair-Deficient Ercc1Δ/- Mice. Aging Cell 24 (2025).
  48. L. Stockmann et al., KIF2A stabilizes intercellular bridge microtubules to maintain mouse embryonic stem cell cytokinesis. The Journal of cell biology 224 (2025).
  49. J. Van De Grint et al., A Reporter Platform to Study Therapy-Induced Senescence in Live Cancer Cells. Small Methods 9 (2025).
  50. G. van de Kamp, I. T. da Silva, S. Barnhoorn, R. Kanaar, J. Essers, Contributions of DNA double strand break repair pathways to DNA crosslink repair. DNA Repair 153 (2025).
  51. G. van de Kamp, T. Heemskerk, M. Rovituso, R. Kanaar, J. Essers, Differential roles of DNA double strand break repair pathways in response to X-ray, proton, and alpha-particle irradiation. International Journal of Radiation Biology 102, 105-115 (2025).
  52. E. D. van Deel et al., Induction of cardiac fibulin-4 protects against pressure overload-induced cardiac hypertrophy and heart failure. Communications Biology 8 (2025).
  53. J. W. van der Meer et al., Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1. Genes and Development 39, 401-422 (2025).
  54. C. van Horik et al., The impact of hyperoxia and antibiotics on lung mesenchymal cells in experimental bronchopulmonary dysplasia. American journal of physiology Lung cellular and molecular physiology 329, L440-L454 (2025).
  55. J. D. Windster et al., Human enteric glia diversity in health and disease. new avenues for the treatment of Hirschsprung disease 168, 965-979 (2025).
  56. H. Wu et al., Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes. Disease Models & Mechanisms 18 (2025).
  57. C. Yang et al., Fingolimod Prevents Neuroinflammation but Has a Limited Effect on the Development of Ataxia in a Mouse Model for SCA1. International Journal of Molecular Sciences 26 (2025).