Publications 2013-2014

Publications in which OIC equipment was used 

  1. Alves, C.H, Bossers, K, Vos, R.M, Essing, A.H.W, Swagemakers, S.M.A, van der Spek, P.J, … Wijnholds, J. (2013). Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background. PLoS ONE, 8 (12). 
  2. Atlasi Y, Noori R, Gaspar C, Franken P, Sacchetti A, Rafati H, Mahmoudi T, Decraene C, Calin GA, Merrill BJ, Fodde R (2013). Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation. PLoS Genet. 9 (5):e1003424. 
  3. Boisset JC, Clapes T, Van Der Linden R, Dzierzak E, Robin C (2013). Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open. 2 (5):525-32. 
  4. Broekhuis JR, Rademakers S, Burghoorn J, Jansen G (2013). SQL-1, homologue of the Golgi protein GMAP210, modulates intraflagellar transport in C. elegans. J Cell Sci. 126 (Pt 8):1785-95. 
  5. Campalans, A, Kortulewski, T, Amouroux, R, Menoni, H, Vermeulen, W and Radicella JP (2013). Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair. Nucleic Acids Res. 41: 3115-29. 
  6. Carofiglio F, Inagaki A, de Vries S, Wassenaar E, Schoenmakers S, VermeulenC, van Cappellen WA, Sleddens-Linkels E, Grootegoed JA, Te Riele HP, de Massy B, Baarends WM. (2013) SPO11-independent DNA repair foci and their role in meioticsilencing. PLoS Genet. 9 (6):e1003538. 
  7. de Pater E, Kaimakis P, Vink CS, Yokomizo T, Yamada-Inagawa T, van der Linden R, Kartalaei PS, Camper SA, Speck N, Dzierzak E (2013). Gata2 is required for HSC generation and survival. J Exp Med. 210 (13):2843-50. 
  8. Dicheva BM, ten Hagen TL, Li L, Schipper D, Seynhaeve AL, van Rhoon GC, Eggermont AM, Lindner LH, Koning GA (2013). Cationic thermosensitive liposomes: a novel dual targeted heat-triggered drug delivery approach for endothelial and tumor cells. Nano Lett. 13 (6):2324-31. 
  9. Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, GrosbartM, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB,Vermeulen W, Marteijn JA. (2013) Enhanced chromatin dynamics by FACT promotestranscriptional restart after UV-induced DNA damage. Mol Cell. 51 (4):469-79 
  10. Doyen CM, Moshkin YM, Chalkley GE, Bezstarosti K, Demmers JA, Rathke C, Renkawitz-Pohl R, Verrijzer CP (2013). Subunits of the histone chaperone CAF1 also mediate assembly of protamine-based chromatin. Cell Rep. 4 (1):59-65. 
  11. Elfferich P, van Royen ME, van de Wijngaart DJ, Trapman J, Drop SL, van denAkker EL, Lusher SJ, Bosch R, Bunch T, Hughes IA, Houtsmuller AB, Cools M, FaradzSM, Bisschop PH, Bunck MC, Oostdijk W, Brüggenwirth HT, Brinkmann AO. (2013) Variableloss of functional activities of androgen receptor mutants in patients withandrogen insensitivity syndrome. Sex Dev. 7 (5):223-34. 
  12. Galliano, E, Baratella, M, Sgritta, M, Ruigrok, T.J.H, Haasdijk, E.D, Hoebeek, F.E, … de Zeeuw, C.I. (2013). Anatomical investigation of potential contacts between climbing fibers and cerebellar golgi cells in the mouse. Frontiers in Neural Circuits 7:59. 
  13. Ghamari A, van de Corput MP, Thongjuea S, van Cappellen WA, van Ijcken W, vanHaren J, Soler E, Eick D, Lenhard B, Grosveld FG. (2013) In vivo live imaging of RNApolymerase II transcription factories in primary cells. Genes Dev. 27 (7):767-77. 
  14. Jensen K, Rother MB, Brusletto BS, Olstad OK, Dalsbotten Aass HC, van Zelm MC, Kierulf P, Gautvik KM (2013). Increased ID2 levels in adult precursor B cells as compared with children is associated with impaired Ig locus contraction and decreased bone marrow output. J Immunol.191 (3):1210-9. 
  15. Kersseboom S, Kremers GJ, Friesema EC, Visser WE, Klootwijk W, Peeters RP, Visser TJ. (2013) Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution. Mol Endocrinol.27 (5):801-13. 
  16. Lans H, Lindvall JM, Thijssen K, Karambelas AE, Cupac D, Fensgård O, Jansen G, Hoeijmakers JH, Nilsen H, Vermeulen W. (2013) DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals Cell Death Differ 20: 1709-18 
  17. Leslie, K., and Galjart, N. (2013). Going solo: measuring the motions of microtubules with an in vitro assay for TIRF microscopy. Methods Cell Biol 115, 109-124. 
  18. Li L, ten Hagen TL, Bolkestein M, Gasselhuber A, Yatvin J, van Rhoon GC, Eggermont AM, Haemmerich D, Koning GA (2013). Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia. J Control Release. 167 (2):130-7. 
  19. Li L, ten Hagen TL, Hossann M, Süss R, van Rhoon GC, Eggermont AM, Haemmerich D, Koning GA (2013). Mild hyperthermia triggered doxorubicin release from optimized stealth thermosensitive liposomes improves intratumoral drug delivery and efficacy. J Control Release. 168 (2):142-50. 
  20. Middelburg TA, de Bruijn HS, Tettero L, van der Ploeg van den Heuvel A (2013), Neumann HA, de Haas ER, Robinson DJ. Topical hexylaminolevulinate and aminolevulinic acid photodynamic therapy: complete arteriole vasoconstriction occurs frequently and depends on protoporphyrin IX concentration in vessel wall. J Photochem Photobiol B. 126: 26-32. 
  21. Moshkin YM, Doyen CM, Kan TW, Chalkley GE, Sap K, Bezstarosti K, Demmers JA, Ozgur Z, van Ijcken WF, Verrijzer CP (2013). Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A. PLoS Genet. 9 (9):e1003719. 
  22. Mustafa D, Swagemakers S, French P, Luider TM, van der Spek P, Kremer A, Kros JM (2013). Structural and expression differences between the vasculature of pilocytic astrocytomas and glioblastomas. J Neuropathol Exp Neurol. 72 (12):1171-81. 
  23. Pedrosa LR, van Hell A, Süss R, van Blitterswijk WJ, Seynhaeve AL, vanCappellen WA, Eggermont AM, ten Hagen TL, Verheij M, Koning GA. (2013) Improvingintracellular doxorubicin delivery through nanoliposomes equipped with selective tumor cell membrane permeabilizing short-chain sphingolipids. Pharm Res. 30 (7):1883-95. 
  24. Rahmati N, Kunzelmann K, Xu J, Barone S, Sirianant L, De Zeeuw CI, Soleimani M (2013). Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H+-ATPase. Pflugers Arch 465 (11): 1583-97. 
  25. Ramakrishnaiah V, Thumann C, Fofana I, Habersetzer F, Pan Q, de Ruiter PE, Willemsen R, Demmers JA, Stalin Raj V, Jenster G, Kwekkeboom J, Tilanus HW, Haagmans BL, Baumert TF, van der Laan LJ (2013). Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells. Proc Natl Acad Sci U S A. 110 (32):13109-13. 
  26. Rüdiger, H, Geis, H.R.A.P, Gerard, J, & Borst, G. (2013). Large GABAergic neurons form a distinct subclass within the mouse dorsal cortex of the inferior colliculus with respect to intrinsic properties, synaptic inputs, sound responses, and projections. The Journal of Comparative Neurology, 521 (1), 189–202. 
  27. Ruiz-Saenz, A., van Haren, J., Laura Sayas, C., Rangel, L., Demmers, J., Millan, J., Alonso, M.A., Galjart, N., and Correas, I. (2013). Protein 4.1R binds to CLASP2 and regulates dynamics, organization and attachment of microtubules to the cell cortex. J Cell Sci 126, 4589-4601. 
  28. Sepe S, Nardacci R, Fanelli F, Rosso P, Bernardi C, Cecconi F, Mastroberardino PG, Piacentini M, Moreno S (2013). Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging. Neurobiol Aging 35 (1):96-108. 
  29. Seynhaeve AL, Dicheva BM, Hoving S, Koning GA, ten Hagen TL (2013). Intact Doxil is taken up intracellularly and released doxorubicin sequesters in the lysosome: evaluated by in vitro/in vivo live cell imaging. J Control Release. 172 (1):330-40. 
  30. Smeenk G, Wiegant WW, Marteijn JA, Luijsterburg MS, Sroczynski N, Costelloe T, Romeijn RJ, Pastink A, Mailand N, Vermeulen W, van Attikum H (2013) Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling. J Cell Sci 126: 889-903 PDF 
  31. Theil AF, Nonnekens J, Steurer B, Mari PO, de Wit J, Lemaitre C, Marteijn JA, Raams A, Maas A, Vermeij M, Essers J, Hoeijmakers JH, Giglia-Mari G, Vermeulen W (2013) Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality. PLoS Genet 9 (4):e1003431 
  32. van de Werken C, Jahr H, Avo Santos M, Eleveld C, Schuilwerve J, Laven JS, Baart EB (2013) A universal method for sequential immunofluorescent analysis of chromatin and chromatin-associated proteins on chromosome spreads. Chromosome Research 21: 475-89 
  33. van der Zee M, Jia Y, Wang Y, Heijmans-Antonissen C, Ewing PC, Franken P, DeMayo FJ, Lydon JP, Burger CW, Fodde R, Blok LJ (2013). Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression. J Pathol. 230 (1):48-58. 
  34. van Royen ME, van de Wijngaart DJ, Cunha SM, Trapman J, Houtsmuller AB. (2013) A multi-parameter imaging assay identifies different stages of ligand-inducedandrogen receptor activation. Cytometry A. 83 (9):806-17. 
  35. van Soest, R. J.; van Royen, M. E.; de Morree, E. S.; et al. (2013). Cross-resistance between taxanes and new hormonal agents abiraterone and enzalutamide may affect drug sequence choices in metastatic castration-resistant prostate cancer. EUROPEAN JOURNAL OF CANCER Volume: 49 Issue: 18 Pages: 3821-3830 
  36. van Soest, Robert J.; van Royen, Martin E.; de Morree, Ellen S.; et al. (2013). Effects on androgen receptor nuclear import by docetaxel, cabazitaxel, abiraterone, and enzalutamide: Potential mechanism for cross-resistance in castration-resistant prostate cancer (CRPC). Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) Location: Chicago, IL Date: MAY 31-JUN 04, 2013 JOURNAL OF CLINICAL ONCOLOGY Volume: 31 Issue: 15 Supplement: S Meeting Abstract: 5064 
  37. van Velzen, M, Jing, L, Osterhaus, A.D.M.E, Sette, A, Koelle, D.M, & Verjans, G.M.G.M. (2013). Local CD4 and CD8 T-Cell Reactivity to HSV-1 Antigens Documents Broad Viral Protein Expression and Immune Competence in Latently Infected Human Trigeminal Ganglia. PL o S Pathogens (Online), 9 (8), 1–11. 
  38. Zhao T, PhD, Severijnen LA, Van der Weiden M, Zheng PP, Oostra BA, Hukema RK, Willemsen R, Kros JM, Bonifati V (2013). FBXO7 immunoreactivity in α-Synuclein-Containing Inclusions in Parkinson Disease and Multiple-System Atrophy. J Neuropathol Exp Neurol 72 (6): 482-8. 
  39. Aydin OZ, Marteijn JA, Ribeiro-Silva C, Rodríguez López A, Wijgers N, Smeenk G, van Attikum H, Poot RA, Vermeulen W, Lans H (2014) Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription. Nucleic Acids Res. 42: 8473-8485 
  40. Barnhoorn S, Uittenboogaard LM, Jaarsma D, Vermeij WP, Tresini M, Weymaere M, Menoni H, Brandt RM, de Waard MC, Botter SM, Sarker AH, Jaspers NG, van der Horst GT, Cooper PK, Hoeijmakers JH, van der Pluijm I. (2014). Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency. PLoS Genet. 10 (10):e1004686. 
  41. Basu S, Sladecek S, Pemble H, Wittmann T, Slotman JA, van Cappellen W, BrennerHR, Galjart N. (2014) Acetylcholine receptor (AChR) clustering is regulated both byglycogen synthase kinase 3β (GSK3β)-dependent phosphorylation and the level ofCLIP-associated protein 2 (CLASP2) mediating the capture of microtubuleplus-ends. J Biol Chem. 289 (44):30857-67. 
  42. Bergs JW, Neuendorff N, van der Heijden G, Wassenaar E, Rexin P, Elsasser HP, Moll R, Baarends WM, Brehm A (2014). Differential expression and sex chromosome association of CHD3/4 and CHD5 during spermatogenesis. PloS one 9: e98203. 
  43. Boekhoorn, S, van Dis, V, Goedknegt, E, Sobel, A, Lucassen, P.J, & Hoogenraad, C.C. (2014). The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis. Developmental Neurobiology 74 (12):1226-42 
  44. Broekhuis JR, Verhey KJ, Jansen G (2014). Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. PLoS One. 9 (9):e108470. 
  45. Broekhuis, J.R., Verhey, K.J. & Jansen, G. (2014) Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. PLoS One 9, e108470. 
  46. Buijsen RA, Sellier C, Severijnen LA, Oulad-Abdelghani M, Verhagen RF, Berman RF, Charlet-Berguerand N, Willemsen R, Hukema RK (2014). FMRpolyG-positive inclusions in CNS and non-CNS organs of a fragile X premutation carrier with fragile X-associated tremor/ataxia syndrome. Acta Neuropathol Commun. 2 (1):162. 
  47. Delhanty PJ, Bouw E, Huisman M, Vervenne RM, Themmen AP, van der Lely AJ, van den Akker EL (2014). Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity. Mol Biol Rep. 41 (12):7967-72. 
  48. Dicheva BM, ten Hagen TL, Schipper D, Seynhaeve AL, van Rhoon GC, Eggermont AM, Koning GA (2014). Targeted and heat-triggered doxorubicin delivery to tumors by dual targeted cationic thermosensitive liposomes. J Control Release. 195: 37-48. 
  49. Eini, R, Stoop, J.A, Gillis, A.J.M, Biermann-Pauls, K, Dorssers, L.C.J, & Looijenga, L.H.J. (2014). Role of SOX2 in the etiology of embryonal carcinoma, based on analysis of the NCCIT and NT2 cell lines. PLoS ONE, 9 (1). 
  50. Giraud G, Stadhouders R, Conidi A, Dekkers DH, Huylebroeck D, Demmers JA, Soler E, Grosveld FG (2014). NLS-tagging: an alternative strategy to tag nuclear proteins. Nucleic Acids Res. 2014 Dec 1;42(21). 
  51. Gourdin AM, van Cuijk L, Tresini M, Luijsterburg MS, Nigg AL, Giglia-Mari G,Houtsmuller AB, Vermeulen W, Marteijn JA. (2014) Differential binding kinetics ofreplication protein A during replication and the pre- and post-incision steps of nucleotide excision repair. DNA Repair 24: 46-56. 
  52. Groeneweg S, Friesema EC, Kersseboom S, Klootwijk W, Visser WE, Peeters RP, Visser TJ (2014). The role of Arg445 and Asp498 in the human thyroid hormone transporter MCT8. Endocrinology. 155 (2):618-26. 
  53. Gül N, Babes L, Siegmund K, Korthouwer R, Bögels M, Braster R, Vidarsson G, ten Hagen TL, Kubes P, van Egmond M (2014). Macrophages eliminate circulating tumor cells after monoclonal antibody therapy. J Clin Invest. 124 (2):812-23. 
  54. Hernanda PY, Chen K, Das AM, Sideras K, Wang W, Li J, Cao W, Bots SJ, Kodach LL, de Man RA, Ijzermans JN, Janssen HL, Stubbs AP, Sprengers D, Bruno MJ, Metselaar HJ, Ten Hagen TL, Kwekkeboom J, Peppelenbosch MP, Pan Q (2014). SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma. Oncogene. 2014 Dec 22. doi: 10.1038/onc.2014.425. [Epub ahead of print] PMID: 25531314 
  55. Imanirad P, Solaimani Kartalaei P, Crisan M, Vink C, Yamada-Inagawa T, de Pater E, Kurek D, Kaimakis P, van der Linden R, Speck N, Dzierzak E (2014). HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo. Stem Cell Res. 12 (1):24-35. 
  56. Kapere Ochieng J, Schilders K, Kool H, Buscop-van Kempen M, Boerema-De Munck A, Grosveld F, Wijnen R, Tibboel D, Rottier RJ (2014). Differentiated type II pneumocytes can be reprogrammed by ectopic Sox2 expression. PLoS One. 9 (9):e107248. 
  57. Kaščáková, S, Hofland, L.J, de Bruijn, H.S, Ye, Y, Achilefu, S, van der Wansem, K, … van Hagen, M.P. (2014). Somatostatin analogues for receptor targeted photodynamic therapy. PLoS ONE, 9 (8). 
  58. Li L, ten Hagen TL, Haeri A, Soullié T, Scholten C, Seynhaeve AL, Eggermont AM, Koning GA (2014). A novel two-step mild hyperthermia for advanced liposomal chemotherapy. J Control Release. 174: 202-8. 
  59. Middelburg TA, de Vijlder HC, de Bruijn HS, van der Ploeg-van den Heuvel A, Neumann HA, de Haas ER, Robinson DJ (2014). Topical photodynamic therapy using different porphyrin precursors leads to differences in vascular photosensitization and vascular damage in normal mouse skin. Photochem Photobiol. 90 (4):896-902. 
  60. Pedrosa LR, Ten Hagen TL, Süss R, van Hell A, Eggermont AM, Verheij M, Koning GA (2014). Short-Chain Glycoceramides Promote Intracellular Mitoxantrone Delivery from Novel Nanoliposomes into Breast Cancer Cells. Pharm Res. 2014 Oct 16. [Epub ahead of print] 
  61. Pop AS, Levenga J, de Esch CE, Buijsen RA, Nieuwenhuizen IM, Li T, Isaacs A, Gasparini F, Oostra BA, Willemsen R. Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant. Psychopharmacology (Berl). 231 (6):1227-35. 
  62. Raghoebir, L, Biermann-Pauls, K, van Kempen, M, Dubbink, H.J, Dinjens, W.N.M, Hersmus, R, … Smits, R. (2014). Aberrant SOX2 expression in colorectal cancers does not correlate with mucinous differentiation and gastric mucin MUC5AC expression. Virchows Archiv. 465 (4):395-400 
  63. Rathke C, Baarends WM, Awe S, Renkawitz-Pohl R (2014). Chromatin dynamics during spermiogenesis. Biochim Biophys Acta 1839: 155-168. 
  64. Reddy BA, van der Knaap JA, Bot AG, Mohd-Sarip A, Dekkers DH, Timmermans MA, Martens JW, Demmers JA, Verrijzer CP (2014). Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization. Mol Cell. 53 (3):458-70. 
  65. Reuter M, Zelensky A, Smal I, Meijering E, van Cappellen WA, de Gruiter HM,van Belle GJ, van Royen ME, Houtsmuller AB, Essers J, Kanaar R, Wyman C. (2014) BRCA2diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells. J Cell Biol. 207 (5):599-613. 
  66. Sanchez H, Reuter M, Yokokawa M, Takeyasu K, Wyman C (2014). Taking it one step at a time in homologous recombination repair. DNA Repair (Amst). 20: 110-8. 
  67. Skachkov, I., Luan, Y., van der Steen, A.F.W., de Jong, N., Kooiman, K. (2014). Targeted microbubble mediated sonoporation of endothelial cells in vivo. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control; 61: p. 1661-1667. 
  68. Stadhouders R, de Bruijn MJ, Rother MB, Yuvaraj S, Ribeiro de Almeida C, Kolovos P, Van Zelm MC, van Ijcken W, Grosveld F, Soler E, Hendriks RW (2014). Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions. PLoS Biol. 12 (2):e1001791. 
  69. van de Werken C, van der Heijden GW, Eleveld C, Teeuwssen M, Albert M, Baarends WM, Laven JS, Peters AH, Baart EB (2014). Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications. Nature communications 5: 5868. 
  70. van Hagen P, Biermann K, Boers JE, Stoss O, Sleddens HF, van Lanschot JJ, Dinjens WN, Rueschoff J, Wijnhoven BP (2014). Human epidermal growth factor receptor 2 overexpression and amplification in endoscopic biopsies and resection specimens in esophageal and junctional adenocarcinoma. Dis Esophagus. 2014 Mar 10. doi: 10.1111/dote.12204. [Epub ahead of print] PubMed PMID: 24611982. 
  71. van Haren, J., Boudeau, J., Schmidt, S., Basu, S., Liu, Z., Lammers, D., Demmers, J., Benhari, J., Grosveld, F., Debant, A., and Galjart, N. (2014). Dynamic Microtubules Catalyze Formation of Navigator-TRIO Complexes to Regulate Neurite Extension. Curr Biol 24, 1778-1785. 
  72. van Leeuwen-van Zaane F, van Driel PB, Gamm UA, Snoeks TJ, de Bruijn HS, van der Ploeg-van den Heuvel A, Löwik CW, Sterenborg HJ, Amelink A, Robinson DJ (2014). Microscopic analysis of the localization of two chlorin-based photosensitizers in OSC19 tumors in the mouse oral cavity. Lasers Surg Med. 2014 Mar;46(3):224-34. 
  73. Wong HT, Chiu WZ, Breedveld GJ, Li KW,Verkerk AJMH, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JHG, van Duinen SG, Kamphorst W, Rozemuller AJ, Netherlands Brain Bank, Bakker EB, The International Parkinsonism Genetics Network, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J (2014).PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology. Brain 137 (pt5): 1361-73. 
  74. Zhou X, Wang Y, Metselaar HJ, Janssen HL, Peppelenbosch MP, Pan Q. (2014) Rapamycin and everolimus facilitate hepatitis E virus replication: revealing a basal defense mechanism of PI3K-PKB-mTOR pathway. J Hepatol. 61 (4):746-54.